Publications by authors named "D E McGraw"

Introduction: The rapid advancement of artificial intelligence (AI) has led to significant transformations in health and healthcare. As AI technologies continue to evolve, there is an urgent need to establish a unified framework that guides the design, implementation, and evaluation of AI-driven interventions across individual and population health contexts.

Approach: In response to this need, the National Academy of Medicine (NAM) has initiated the development of an AI code of conduct (AICC) through its Digital Health Action Collaborative.

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Article Synopsis
  • A study examined the impact of weight-based dosing strategies on valproic acid (VPA) effectiveness and safety in both obese and nonobese patients, aiming to address the variability in drug absorption and response due to body weight.
  • The analysis, involving 186 patients, revealed no significant difference in VPA serum levels but showed that obese patients received lower doses (15.6 mg/kg) compared to nonobese patients (19.5 mg/kg), with a stronger correlation found between VPA dose and serum levels in the obese group.
  • The researchers suggested that using adjusted body weight (AdjBW) for dosing in obese patients may reduce the risk of toxicity, recommending further studies with larger
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The analysis of big healthcare data has enormous potential as a tool for advancing oncology drug development and patient treatment, particularly in the context of precision medicine. However, there are challenges in organizing, sharing, integrating, and making these data readily accessible to the research community. This review presents five case studies illustrating various successful approaches to addressing such challenges.

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Big data in healthcare can enable unprecedented understanding of diseases and their treatment, particularly in oncology. These data may include electronic health records, medical imaging, genomic sequencing, payor records, and data from pharmaceutical research, wearables, and medical devices. The ability to combine datasets and use data across many analyses is critical to the successful use of big data and is a concern for those who generate and use the data.

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