Publications by authors named "D E Mayock"
Background: Both perinatal arterial ischemic stroke (PAIS) and hypoxic-ischemic encephalopathy (HIE) can present with neonatal encephalopathy. We hypothesized that among infants undergoing therapeutic hypothermia, presence of PAIS is associated with a higher risk of seizures and a lower risk of persistent encephalopathy after rewarming.
Methods: We studied 473 infants with moderate or severe HIE enrolled in the HEAL Trial who received a brain MRI.
Article Synopsis
- Infants with hypoxic ischemic encephalopathy (HIE) may have underlying genetic or congenital anomalies, which could influence their health outcomes, but the extent of this impact is not well understood.
- In a study of 500 infants with HIE, 5% were found to have genetic or congenital anomalies; these infants showed higher rates of death or neurodevelopmental impairment (NDI) compared to those without anomalies.
- Despite similar severity of HIE, infants with genetic or congenital issues had worse neurological outcomes, including higher instances of cerebral palsy and lower developmental scores at age two.
Objective: To assess among a cohort of neonates with hypoxic-ischemic encephalopathy (HIE) the association of pretreatment maximal hourly seizure burden and total seizure duration with successful response to initial antiseizure medication (ASM).
Study Design: This was a retrospective review of data collected from infants enrolled in the HEAL Trial (NCT02811263) between January 25, 2017, and October 9, 2019. We evaluated a cohort of neonates born at ≥36 weeks of gestation with moderate-to-severe HIE who underwent continuous electroencephalogram monitoring and had acute symptomatic seizures.
Objective: Determine association between time to regain birthweight and 2-year neurodevelopment among extremely preterm (EP) newborns.
Study Design: Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial evaluating time to regain birthweight, time from birth to weight nadir, time from nadir to regain birthweight, and cumulative weight loss with 2-year corrected Bayley Scales of Infant and Toddler Development 3rd edition.
Results: Among n = 654 EP neonates, those with shorter nadir-to-regain had lower cognitive scores (≤1 day versus ≥8 days: -5.
Background: Associations of 2-year neurodevelopmental and behavioral outcomes with growth trajectories of preterm infants are unknown.
Methods: This secondary analysis of a preterm cohort examined in-hospital and discharge to 2-year changes in anthropometric z-scores. Two-year follow-up included Bayley Scales of Infant Development (BSID-III) and Child Behavior Checklist.