Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease.

Polycystic kidney diseases (PKD) are genetic disorders which disrupt kidney architecture and function. Autosomal recessive PKD (ARPKD) is a rare form of PKD, caused by mutations in PKHD1, and clinically more severe than the more common autosomal dominant PKD (ADPKD). Prior studies have implicated Hedgehog (Hh) signaling in ADPKD, with increased levels of Hh components in experimental ADPKD and reduced cystogenesis following pharmacological Hh inhibition.

Factors associated with cultural sensitivity and global nursing education among nurse educators: A cross-sectional study.

Background: Nurse educators must be culturally sensitive to teach cultural care to nursing students effectively.

Objective: To explore the factors associated with cultural sensitivity and global nursing education among nurse educators.

Methods: This was a cross-sectional exploratory study.

Coherently averaged optical frequency comb spectroscopy with a single electro-optic modulator.

We present a new, to the best of our knowledge, approach for self-heterodyne optical frequency comb (OFC) spectroscopy in which a single Mach-Zehnder modulator is utilized to generate both an optical frequency comb and a frequency-shifted local oscillator. This method allows for coherent, time-domain averaging to be performed without the need for feedback mechanisms or software corrections. As an initial demonstration, we have measured acetylene rovibrational transition frequencies with coherently averaged comb spectra.

Analysis of expression and its clinical significance of the ADAMTS-2 in systemic lupus erythematosus.

Objectives: ADAMTS-2 is a procollagen N-proteinase that plays an important role in inflammation regulation. The objective of our research is to explore the expression of ADAMTS-2 in Systemic Lupus Erythematosus (SLE), and analyze its relationship with clinical features of SLE, and evaluate the potential value of ADAMTS-2 as a diagnostic biomarker in SLE.

Methods: ADAMTS-2 expression in PBMCs was detected by RT-qPCR in SLE patients, RA patients, and healthy controls (HC).

MA Demethyltransferase FTO Attenuates Meniscus Degeneration and Osteoarthritis via Orchestrating Autophagy and Energetic Metabolism.

Impaired autophagy is reported to promote osteoarthritis (OA). However, the mechanism by which autophagy in regulating meniscus degeneration and OA remains unclear. Here, unconvered aberrant energetic metabolism pattern in meniscus cells with OA is uncovered first, which results in lower adenosine triphosphate (ATP) production.