Publications by authors named "D E Linder"

Understanding the role of chemokine receptors in health and disease has been of increasing interest in recent years. Chemokine receptor CXCR4 has been extensively studied because of its defined role in immune cell trafficking, HIV infection, inflammatory diseases, and cancer progression. We have developed high affinity rigidified CXCR4 antagonists that incorporate metal ions to optimize the binding interactions with the aspartate side chains at the extracellular surface of the CXCR4 chemokine receptor and increase the residence time.

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Article Synopsis
  • The EADV Task Forces analyzed the Health-Related Quality of Life (HRQoL) measurement in urticaria treatment, highlighting the Dermatology Life Quality Index as the most commonly used tool in clinical trials.
  • Many trials lacked specific numeric results on HRQoL changes, complicating comparisons and conclusions across studies.
  • The study suggests favoring HRQoL instruments that include minimal clinically significant difference (MCID) data for better relevance in clinical practice rather than just relying on statistically significant changes.
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The European Academy of Dermatology and Venereology (EADV) Task Forces on quality of life (QoL) and patient-oriented outcomes and on urticaria and angioedema recommendations for the assessment of Health-related (HR) QoL in all patients with urticaria in research and practice are as follows: to use the DLQI for adults and the CDLQI for children as dermatology-specific and the CU-Q2oL as a disease-specific HRQoL instruments in urticaria; to use generic instruments to provide comparison of data on urticaria with non-dermatologic diseases, or to compare with healthy volunteers or the general population; to select validated HRQoL instruments with appropriate age limits; to present exact numeric data for HRQoL results; correct title of any HRQoL instrument should be used, along with its correct abbreviation and the reference to its original publication, where possible. The EADV TFs discourage the use of non-validated HRQoL instruments and modified HRQoL instruments that have not undergone standard validation.

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Background: At an individual level, physician resilience protects against burnout and against its known negative effects on individual physicians, patient safety, and quality of care. However, it remains uncertain whether physician resilience also correlates with maintaining a high level of healthcare quality during crises such as a pandemic. This study aimed to investigate whether higher resilience among physicians, who had received training in resilience-related competences in the past, would be associated with higher quality of care delivered during the COVID-19 pandemic.

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Article Synopsis
  • The study examines the role of statin use in reducing mortality among hospitalized African American COVID-19 patients, analyzing data from 735 individuals treated at a health system in Georgia.
  • Statin use during hospitalization was not found to significantly affect overall mortality rates or secondary outcomes like ICU care or need for mechanical ventilation.
  • It was noted that severe disease presentation and immunosuppression were linked to a notably higher risk of mortality in this population.
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