Publications by authors named "D E Krebs"
Lesbian, gay, bisexual, transgender, queer, and all sexually and gender diverse (LGBTQ+) youth with HIV face multiple barriers to progression along the HIV care continuum. We searched PubMed, PsycInfo, clinicaltrials.gov, and the Adolescent Medicine Trials Network for HIV/AIDS Interventions for interventions focused on improving linkage to care, retention in care, adherence to antiretroviral therapy, or viral suppression (VS) among LGBTQ+ youth with HIV in the United States.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess the degeneration of the corticospinal tract (CST) and corpus callosum (CC) in motor neuron disease patients using diffusion kurtosis imaging (DKI).
- It involved 27 patients and 33 healthy controls, utilizing MRI and clinical assessments to analyze differences in brain microstructure and disease correlation.
- Results showed significant differences in diffusion metrics between patients and controls, indicating potential use of DKI as a biomarker for cerebral degeneration in conditions like amyotrophic lateral sclerosis.
Unlabelled: While immunotherapies such as immune checkpoint blockade and adoptive T-cell therapy improve survival for a subset of human malignancies, many patients fail to respond. Phagocytes including dendritic cells (DC), monocytes, and macrophages (MF) orchestrate innate and adaptive immune responses against tumors. However, tumor-derived factors may limit immunotherapy effectiveness by altering phagocyte signal transduction, development, and activity.
View Article and Find Full Text PDFMotor cortex functional connectivity is associated with underlying neurochemistry in ALS.
J Neurol Neurosurg Psychiatry
March 2023
Article Synopsis
- The study investigates the structural and neurochemical factors affecting motor cortex connectivity in ALS patients compared to healthy controls.
- 52 ALS patients and 52 matched controls underwent various imaging techniques to analyze brain connectivity and motor function.
- Results show that ALS patients had reduced connectivity in the primary motor cortex and altered neurochemical markers, correlating with difficulties in motor tasks like foot tapping.
- The findings suggest that neurochemical indicators, such as N-acetyl aspartate levels, could serve as valuable markers for assessing motor cortex connectivity impairments in ALS.
Article Synopsis
- Clinicians across various medical fields will likely encounter transgender and gender-diverse (TGD) youth, making it important for them to understand how to affirm these individuals in care.
- Gender-affirming therapy includes recognizing preferred names and pronouns, and the transition process can vary greatly among patients, potentially involving both medical and nonmedical interventions.
- Medical treatments for gender transition can affect physical health aspects like growth and fertility, so clinicians should inform patients and families about known risks while collaborating on personalized treatment plans.