Publications by authors named "D E Kleiner"
Background And Aims: Short courses of intravenous (iv) methylprednisolone (MP) can cause drug induced liver injury (DILI). The aim of this study was to assess the clinical features and HLA associations of MP-related DILI enrolled in the US DILI Network (DILIN).
Methods: DILIN cases with MP as a suspected drug were reviewed.
Saliva contains antimicrobial peptides considered integral components of host innate immunity, and crucial for protection against colonizing microbial species. Most notable is histatin-5 which is exclusively produced in salivary glands with uniquely potent antifungal activity against the opportunistic pathogen Candida albicans. Recently, SARS-CoV-2 was shown to replicate in salivary gland acinar cells eliciting local immune cell activation.
View Article and Find Full Text PDFObjectives: Concerns about drug-induced liver injury (DILI) may deter physicians from prescribing medications for alcohol use disorder (MAUD). We aim to explore DILI due to MAUD in Drug-Induced Liver Injury Network (DILIN) prospective study.
Methods: High-confidence DILI cases (ie, definite, highly likely, or probable) due to MAUD in DILIN prospective study (2004-2024) were included.
Article Synopsis
- Intra and inter-pathologist variability complicates the evaluation of metabolic dysfunction-associated steatohepatitis (MASH) biopsy results, hindering patient selection and assessment quality in clinical trials.
- A study analyzed 120 histology slides with and without AI assistance to evaluate its impact on pathologists' reliability in fibrosis staging, especially for early fibrosis stages.
- Results showed that AI assistance significantly improved concordance among pathologists, increasing agreement rates for clinical trial inclusion and exclusion, which could enhance the overall efficiency and reliability of MASH-related clinical research.