Doxycycline Versus Vancomycin for the Treatment of Methicillin-Resistant Acute Pulmonary Exacerbations in People With Cystic Fibrosis.

Background: Among people with cystic fibrosis (PwCF), methicillin-resistant (MRSA)-associated acute pulmonary exacerbations (APEs) have been increasing in prevalence and can cause rapid declines in lung function and increased mortality. Fortunately, since 2019, incidence has started to decline.

Objective: The purpose of this study was to evaluate if doxycycline has comparable efficacy to vancomycin for the treatment of APEs in PwCF.

Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation.

Sequence-based machine-learning models trained on genomics data improve genetic variant interpretation by providing functional predictions describing their impact on the cis-regulatory code. However, current tools do not predict RNA-seq expression profiles because of modeling challenges. Here, we introduce Borzoi, a model that learns to predict cell-type-specific and tissue-specific RNA-seq coverage from DNA sequence.

Modifying Informed Consent to Help Address Functional Unmasking in Psychedelic Clinical Trials.

Importance: There is unprecedented clinician, industry, and patient interest in the therapeutic development of psychedelic drugs. This is due to a combination of promising clinical trial results, positive media coverage, and the lack of novel pharmacologic treatments for psychiatric disorders in recent decades. However, the field faces a key methodological challenge: masking participants to treatment conditions in psychedelic clinical trials has been largely unsuccessful.

Exposure to novel females increases fecundity in adult male prairie voles.

Social circuitry of the mammalian brain can influence male reproductive physiology. This often manifests as plasticity in sperm production or allocation, particularly in response to male-male competition. However, socially mediated testicular plasticity has not been investigated with respect to mating and parental strategy.

Detecting changes in tobacco product marketplace prominence using social media, advertising, sales, and web traffic data: The example of Puff Bar in the United States tobacco marketplace from 2019 to 2021.

Puff Bar, a disposable electronic nicotine delivery system (ENDS), was the ENDS brand most commonly used by U.S. youth in 2021.