Publications by authors named "D E Kaese"
Article Synopsis
- The study aimed to explore the relationship between elevated serum cancer antigen (CA 125) levels and liver disease, particularly focusing on whether CA 125 is produced by the peritoneum in response to excess fluid.
- Elevated CA 125 levels were found in patients with various liver diseases, especially those suffering from cirrhotic ascites, regardless of their specific liver condition or complications.
- The findings suggest that the increase in CA 125 is not merely a nonspecific reaction to fluid accumulation, highlighting the importance of recognizing this association to avoid unnecessary surgeries in affected patients.
Spontaneous bacterial peritonitis is a life-threatening complication of cirrhotic ascites. Optimal patient management depends on the isolation of the causal organism from ascitic fluid. To evaluate culture techniques for the diagnosis of spontaneous bacterial peritonitis, we prospectively compared three blood culture system, the Isolator system, a lysis-centrifugation system, the Septi-Chek system, a biphasic culture system, and a nonvented tryptic soy broth system, all inoculated at the bedside, and our standard method of direct inoculation of specimens after transport to the laboratory onto agar plates and into thioglycolate broth.
View Article and Find Full Text PDFObjectives: to define the roles of the hepatitis C and E viruses (HCV and HEV) in non-A, non-B (NANB) fulminant hepatitis.
Methods: we utilized the polymerase chain reaction to amplify HCV and HEV RNA sequences and assays to detect antibodies to HCV and HEV in the acute phase sera of eight presumed viral NANB and seven nonviral NANB fulminant hepatic failure (FHF) patients.
Results: none of the 15 patients had detectable HCV or HEV RNA or elevated HCV and IgM-HEV antibody titers in their acute phase sera.
Article Synopsis
- The study examined how often spontaneous bacterial peritonitis (SBP), bacterascites (BA), and culture-negative neutrocytic ascites (CNNA) occur in patients with different types of liver diseases, including alcoholic, cholestatic, and hepatocellular liver disease.
- The analysis included 113 patients with a similar procedure to assess their ascitic fluid, revealing that the overall prevalence of peritonitis was 7%, with no significant differences based on liver disease type.
- The findings suggest that neither the type nor severity of liver disease, nor the total protein content in ascitic fluid, reliably predicts the occurrence of peritonitis in these patients.
We retrospectively reviewed the long-term results in 46 patients who survived at least 1 year after liver transplantation. Only one death has occurred, and one patient has required retransplantation. Biochemical liver function tests showed median values in the normal range, except for mild elevation of serum gamma-glutamyltransferase.
View Article and Find Full Text PDF