Publications by authors named "D E Joyce"
Background: East African cichlid fishes have diversified in an explosive fashion, but the (epi)genetic basis of the phenotypic diversity of these fishes remains largely unknown. Although transposable elements (TEs) have been associated with phenotypic variation in cichlids, little is known about their transcriptional activity and epigenetic silencing. We set out to bridge this gap and to understand the interactions between TEs and their cichlid hosts.
View Article and Find Full Text PDFIntroduction: Pancreatic ductal adenocarcinoma (PDAC) of the body/tail is notably different than PDAC in the head of the pancreas. Surgery plus chemotherapy is known to improve outcomes for all PDAC. The sequence of this therapy is well studied in head cancers yet has never been evaluated systematically in relation to distal pancreatectomy (DP).
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- The study assesses the risk associated with sub-centimeter Side-Branch Intraductal Papillary Mucinous Neoplasms (SB-IPMN) to inform a surveillance strategy.
- Sub-centimeter SB-IPMNs show a lower rate of clinically relevant progression compared to larger cysts, although they can still develop high-risk pathologies over time.
- The findings suggest that size growth alone is not a reliable indicator of malignant potential, emphasizing the need for careful monitoring regardless of cyst size.
Article Synopsis
- Cancer significantly impacts disabled individuals, who have lower participation rates in population-based screening programs that can aid in early cancer detection.
- A study used qualitative evidence synthesis to analyze 32 publications and identified key factors affecting access to screening, including perceptions, support systems, financial costs, literacy levels, and physical accessibility.
- To improve access, screening services must recognize and address the unique needs of disabled people by implementing reasonable accommodations tailored to their requirements.