Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma.

In this study, we explored the intricate relationship between Pannexin 1 (PANX1) and the Hippo signaling pathway effector, Yes-associated protein (YAP). Analysis of The Cancer Genome Atlas (TCGA) data revealed a significant positive correlation between PANX1 mRNA and core Hippo components, Yes-associated protein 1 [YAP], Transcriptional coactivator with PDZ-binding motif [TAZ], and Hippo scaffold, Ras GTPase-activating-like protein IQGAP1 [IQGAP1], in invasive cutaneous melanoma and breast carcinoma. Furthermore, we demonstrated that PANX1 expression is upregulated in invasive melanoma cell lines and is associated with increased YAP protein levels.

Synthesis and crystal structure of sodium (ethane-1,2-di-yl)bis-[(3-meth-oxy-prop-yl)phosphinodi-thiol-ate] octa-hydrate.

The title compound, -poly[[tri-aqua-sodium]-di-μ-aqua-[tri-aqua-sodium]-μ-(ethane-1,2-di-yl)bis-[(3-meth-oxy-prop-yl)phosphinodi-thiol-ato]], [Na(CHOPS)(HO)] , crystallizes in the triclinic space group 1. The dianionic [CHO(CH)P(=S)(S-)CHCHP(=S)(S-)(CH)OCH] ligand fragments are joined by a dicationic [Na(HO)] cluster that includes the oxygen of the meth-oxy-propyl unit of the ligand to form infinite chains.

Prevalence and molecular characterization of Campylobacter spp. isolated from chicken, beef, pork and sheep livers at Irish abattoirs.

Thermotolerant Campylobacter spp. are the leading causes of food-borne diarrhoea in humans with most cases attributed to C. jejuni, and C.

Intuitive eating predictors and outcomes in people with severe mental illness participating in a lifestyle intervention.

Issue Addressed: People with severe mental illness (SMI) are at higher risk of preventable diseases than the general population; poor diet contributes to heightened risk. Adaptive approaches designed to improve intuitive eating may improve dietary behaviours in people with SMI. Aims of this study were to investigate predictors of, and assess the impact of a nutrition program on, intuitive eating in people with SMI.