Integrative whole slide image and spatial transcriptomics analysis with QuST and QuPath.

The integration of AI in digital pathology, particularly in whole slide image (WSI) and spatial transcriptomics (ST) analysis, holds immense potential for enhancing disease understanding. Despite challenges such as training pattern preparation and resolution disparities, the convergence of these technologies can unlock insights. We introduce QuST, a QuPath extension that bridges the gap between WSI and ST at single-cell level, highlighting the power of this integrated approach in disease biology.

Cross-Cultural Validation of the Binge Eating Disorder Screener-7 (BEDS-7) Across 42 Countries.

Objective: This study aimed to evaluate the reliability and validity of the Binge Eating Disorder Screener-7 (BEDS-7) across 42 countries and 26 languages, assessing its reliability and validity as a screening tool for binge-eating disorder (BED) in diverse cultural contexts. Specifically, it sought to enhance early recognition of BED symptoms in primary care settings globally, contributing to a standardized framework for assessing BED.

Method: The International Sex Survey, a cross-sectional online study, was conducted in 42 countries and 26 languages.

Development of a psychological frailty index: results from the China health and retirement longitudinal study.

Objective: Psychological frailty, an emerging concept, lacks a standardized definition, measuring instrument, and empirical evidence in Asian (especially Chinese) populations. An effective instrument to measure psychological frailty should be urgently developed. Therefore, this study aimed to develop and initially validate a Psychological Frailty Index (PFI) based on the China Health and Retirement Longitudinal Study (CHARLS).

Strontium isotope mapping of elephant enamel supports an integrated microsampling-modeling workflow to reconstruct herbivore migrations.

Strontium isotope ratios (Sr/Sr) in dental tissues are widely used to study animal and human migration. However, questions remain regarding how different biological processes and sampling methods influence measured Sr/Sr and subsequent interpretations. We present a unique experiment with the known relocation history of a zoo elephant to evaluate the influence of biological turnover, tissue type, and sampling methods.