Publications by authors named "D E DeLucia"
Article Synopsis
- Castration-resistant prostate cancer (CRPC) includes various subtypes, notably androgen receptor-active prostate cancer (ARPC) and neuroendocrine prostate cancer (NEPC), which can exist simultaneously in patients, complicating treatment strategies.
- Current therapies lack effectiveness across these different CRPC subtypes, prompting research on a new combined treatment approach.
- The study found that fimepinostat, a dual inhibitor of histone deacetylase (HDAC) and PI3K/AKT, significantly inhibits tumor growth in both ARPC and NEPC models, showing better results when both pathways are targeted together rather than separately.
Article Synopsis
- Scientists are studying how to treat prostate cancer, especially when it's hard to treat (like in castration-resistant prostate cancer or CRPC).
- They've found that some cancers can ignore the usual treatments that work by blocking a protein called the androgen receptor, and they think another pathway called FGFR might be important in these cancers.
- Experiments showed that using FGFR blockers together with existing treatments can help suppress tumor growth, but the effectiveness can vary depending on the specific type of cancer.
The discovery and characterization of antigen-specific CD8 T cell clonotypes typically involves the labor-intensive synthesis and construction of peptide-MHC tetramers. We adapt single-chain trimer (SCT) technologies into a high throughput platform for pMHC library generation, showing that hundreds can be rapidly prepared across multiple Class I HLA alleles. We use this platform to explore the impact of peptide and SCT template mutations on protein expression yield, thermal stability, and functionality.
View Article and Find Full Text PDFAntigen-specific T cell receptor (TCR) sequences can have prognostic, predictive, and therapeutic value, but decoding the specificity of TCR recognition remains challenging. Unlike DNA strands that base pair, TCRs bind to their targets with different orientations and different lengths, which complicates comparisons. We present scanning parametrized by normalized TCR length (SPAN-TCR) to analyze antigen-specific TCR CDR3 sequences and identify patterns driving TCR-pMHC specificity.
View Article and Find Full Text PDFCD8 + cytotoxic T cell responses against viral infection represent a major element of the adaptive immune response. We describe the development of a peptide antigen - major histompatibility complex (pMHC) library representing the full SARS-CoV-2 viral proteome, and comprised of 634 pMHC multimers representing the A*02.01, A*24.
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