Publications by authors named "D E Cowley"
Charcot first described ALS in 1869, but the specific mechanisms that mediate the disease pathology are still not clear. Intense research efforts have provided insight into unique neuroanatomical regions, specific neuronal populations and genetic associations for ALS and other neurodegenerative diseases; however, the experimental results also suggest a convergence of these events to common toxic pathways. We propose that common toxic pathways can be therapeutically targeted, and this intervention will be effective in slowing progression and improving patient quality of life.
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- Adrenal vein sampling (AVS) is the preferred method for identifying unilateral subtypes of primary aldosteronism (PA), which can be treated with surgery for a potential cure.
- The procedure is technically demanding and often performed by specialized interventional radiologists, but variations in protocols can affect its success and patient care.
- To standardize AVS practices and improve outcomes, an Australian and New Zealand AVS Working Group was formed to create expert consensus recommendations that can be utilized by all healthcare professionals involved in PA management.
Article Synopsis
- Mouse models with humanized ACE2 and TMPRSS2 genes were created to study how Th1 and Th2 immune responses affect SARS-CoV-2 infection.
- Mice infected with the Delta variant required ACE2 for lung infection, while Omicron didn't, with Omicron causing more severe disease in specific mouse models.
- The study suggests that the genetic background of the host influences the immune response and severity of SARS-CoV-2 infections, highlighting the need for more research on this variability.
Objective: To systematically review the classification systems for male chronic pelvic pain (CPP).
Methods: The Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica dataBASE (EMBASE), and Web of Science were searched. Any publication, with no restriction to publication date, was eligible.