Publications by authors named "D E Coling"
Article Synopsis
- Various cochlear pathologies lead to hearing loss, and existing hearing impairments can change how the cochlea responds to loud noises.
- The study focuses on prestin, a motor protein crucial for outer hair cell movement in the cochlea, and how its dysfunction affects cochlear responses to acoustic overstimulation.
- A genetic model in mice reveals that prestin dysfunction results in elevated auditory thresholds and altered responses to loud sounds, indicating a diminished ability to handle cochlear stress from noise exposure.
Article Synopsis
- Matrix metalloproteinases (MMPs) play a crucial role in cellular functions and their imbalance is linked to neurological issues and hearing loss.
- In a rat study, MMP activity decreased over time following acoustic trauma, with varying expression found in different regions of the cochlea.
- Short-term use of an MMP inhibitor improved hearing outcomes, while long-term inhibition worsened hearing sensitivity, indicating that properly regulating MMP activity could be a potential treatment to mitigate noise-induced hearing damage.
Ototoxicity remains a major dose-limiting side effect of cisplatin. The current studies were carried out to evaluate the effectiveness of a novel Src-protein tyrosine kinase inhibitor in protecting the ear from cisplatin ototoxicity without compromising cisplatin's antitumor effects. The Src inhibitor has been shown to be effective in protecting the ear from noise-induced hearing loss.
View Article and Find Full Text PDFTyrosine nitration is an important sequel of cellular signaling induced by reactive oxygen species. Cisplatin is an anti-neoplastic agent that damages the inner ear through reactive oxygen species and by the formation of DNA adducts. This study reveals a correlation between cisplatin-mediated hearing loss and nitroxidative modification of cochlear proteins and is the first to report nitration of Lmo4.
View Article and Find Full Text PDFThe biological mechanisms that give rise to age-related hearing loss (ARHL) are still poorly understood. However, there is growing recognition that oxidative stress may be an important factor. To address this issue, we measured the changes in the expression of cochlear oxidative stress and antioxidant defense-related genes in young (2 months old), middle-aged (12 months old), and old (21-25 months old) Fischer 344/NHsd (F344/NHsd) rats and compared gene expression changes with ARHL.
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