Publications by authors named "D E Burleigh"
Background: Ethnicity recording within primary care computerised medical record (CMR) systems is suboptimal, exacerbated by tangled taxonomies within current coding systems.Objective To develop a method for extending ethnicity identification using routinely collected data.
Methods: We used an ontological method to maximise the reliability and prevalence of ethnicity information in the Royal College of General Practitioner's Research and Surveillance database.
Aim: To investigate the impact of glycaemic control on infection incidence in people with Type 2 diabetes.
Methods: We compared infection rates during 2014 in people with Type 2 diabetes and people without diabetes in a large primary care cohort in the UK (the Royal College of General Practitioners Research and Surveillance Centre database). We performed multilevel logistic regression to investigate the impact of Type 2 diabetes on presentation with infection, and the effect of glycaemic control on presentation with upper respiratory tract infections, bronchitis, influenza-like illness, pneumonia, intestinal infectious diseases, herpes simplex, skin and soft tissue infections, urinary tract infections, and genital and perineal infections.
Article Synopsis
- Diabetes doubles the risk of cardiovascular disease, and this study investigates the impact of microvascular complications (like retinopathy and nephropathy) on this risk in patients with type 2 diabetes.
- In a cohort of over 49,000 individuals, significant associations were found between the severity of microvascular disease and the likelihood of experiencing major cardiovascular events, such as heart attacks and strokes.
- The results indicate that a higher number of microvascular disease states correlates with increased cardiovascular risk, suggesting the need for better risk assessment strategies in diabetic patients.
Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial and rate-limiting step of tryptophan degradation along the kynurenine pathway, and is hypothesized to limit tryptophan availability at embryo implantation and prevent maternal T cell activation at the maternal-fetal interface. To determine if nonhuman primates are suitable models for investigating the role of IDO during pregnancy, we defined the expression of IDO in the rhesus monkey and common marmoset with particular attention to the female reproductive tract and placenta. IDO mRNA was detected by RT-PCR in the rhesus monkey term placenta, lung, small intestine, spleen, lymph node and nonpregnant uterus, and also in the common marmoset placenta.
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