Circadian influences on sudden cardiac death and cardiac electrophysiology.

Cardiologists have analyzed daily patterns in the incidence of sudden cardiac death to identify environmental, behavioral, and physiological factors that trigger fatal arrhythmias. Recent studies have indicated an overall increase in sudden cardiac arrest during daytime hours when the frequency of arrhythmogenic triggers is highest. The risk of fatal arrhythmias arises from the interaction between these triggers-such as elevated sympathetic signaling, catecholamine levels, heart rate, afterload, and platelet aggregation-and the heart's susceptibility (myocardial substrate) to them.

Menstrual health symptoms and literacy among young women in Aotearoa New Zealand: A nationwide cross-sectional survey.

Study Objective: To explore menstrual cycle symptoms, information sources and menstrual health literacy in young women (aged 13-25) and those who menstruate in Aotearoa New Zealand.

Design And Setting: Cross-sectional online survey in Aotearoa New Zealand.

Participants: 1334 respondents (age 13-25 years, mean age 19.

Charting water quality improvements and practice reversion with pesticide interventions at catchment scale.

Freshwater quality, and the impacts of farming practice on drinking water supplies, are of concern in many countries and time-limited catchment management interventions are commonly used to improve water quality. However, ending such schemes may result in practice reversion. This study adopts an interdisciplinary approach combining evidence from water quality monitoring data with a behavioural study of farmers to explore changes in land use practice with reference to the pesticide MCPA (2-methyl-4-chlorophenoxyacetic acid) following a catchment-based management scheme delivered in the cross-border Derg catchment in Northern Ireland/Ireland between 2018 and 2021.

Biogeographical Distribution of River Microbial Communities in Atlantic Catchments.

Microbes inhabit virtually all river ecosystems, influencing energy flow and playing a key role in global sustainability and climate change. Yet, there is uncertainty about how various taxonomic groups respond to large-scale factors in river networks. We analysed microbial community richness and composition across six European Atlantic catchments using environmental DNA sequencing.

Long-acting injectable in situ forming implants: Impact of polymer attributes and API.

Poly(DL-lactide-co-glycolide) (PLGA) and N-methyl-2-pyrrolidone (NMP)-based in situ forming implants are liquid formulations that solidify through phase separation following injection into the body. Drug is dissolved or suspended in the final formulation liquid prior to injection. Depending on the polymers used, the depots formed can deliver drug over different periods of time.