Expanding PFAS Identification with Transformation Product Libraries: Nontargeted Analysis Reveals Biotransformation Products in Mice.

Per- and polyfluoroalkyl substances (PFAS) are widely used persistent synthetic chemicals that have been linked to adverse health effects. While the behavior of PFAS has been evaluated in the environment, our understanding of reaction products in mammalian systems is limited. This study identified biological PFAS transformation products and generated mass spectral libraries to facilitate an automated search and identification.

Affectivism and the Emotional Elephant: How a Componential Approach Can Reconcile Opposing Theories to Serve the Future of Affective Sciences.

This article discusses how the and the to emotion may serve the future of affective sciences. A particular aim of the article is to show that an appraisal-based componential approach to emotion can help reconcile opposing theories. It begins by contextualizing the evolution of emotion science within the framework of affectivism, acknowledging that the significant epistemological differences between various theories have paradoxically spurred interest in studying emotion across various perspectives and disciplines.

The added value of affective processes for models of human cognition and learning.

Building on the affectivism approach, we expand on Binz et al.'s meta-learning research program by highlighting that emotion and other affective phenomena should be key to the modeling of human learning. We illustrate the added value of affective processes for models of learning across multiple domains with a focus on reinforcement learning, knowledge acquisition, and social learning.

Enantioselective total synthesis of (+)-cylindricine B.

This article describes the first enantioselective synthesis of the Tasmanian marine alkaloid (+)-cylindricine B. The concise construction of the compound hinged on dearomative retrosynthetic logic combined with a tactical advance in the generation of congested, cyclic, alpha-tertiary amine centers. The scope of this key coupling reaction was explored in addition to providing a synthetic application for Cu-catalyzed enantioselective dearomatization of -acyl-pyridiniums.