[Biopharmaceutical and clinico-pharmacological research on the intramammary preparation Cephamasten].

An animal drug formula, Cephamasten, for intramammary application in the treatment of mastitis-affected cows, ewes, and goats in the lactation period was worked out on the base of microbiologic, technologic, biopharmaceutic, and clinico-pharmacologic studies. Its active ingredient was the Pharmachim cephalexin-monohydrate. The consistence of Cephamasten has proved suitable for intracisternal introduction.

[Preclinical research on drug forms containing rifamycin SV intended for intramammary use].

It was established, that LD50 of rifamycin SV--sodium salt, produced by the Research Institute on Microbiological Industry--Razgrad (People's Republic of Bulgaria)--RM, at p.o. applying on albino mice, albino rats and broilers is correspondingly greater than 4100.

[Postgraduate training in veterinary pharmacology].

The system of postgraduate training of veterinary pharmacology in the European countries is different--in some countries it is connected mainly with the intensive research work and with the obtaining of academic ranks (Ph. D., Dr.

[Efficient drug forms and the means for using them in the intensive raising of animals].

Stated is the use of promising therapeutic formulae that produce prophylactic, metaphylactic, and curative effects at lower input of labour and handling, inciting lower unrest with animals, belonging chiefly to the type of the so-called 'therapeutic systems'. Particular attention is paid to drugs for programmed, continuous, and checkable release of the active ingredients in compliance with what is needed at the time (sustained release forms)-type OROS (oral osmotic system), type 'liquid reservoir', type 'glass cylinders', tablets and boluses of higher relative weight, or multilayer and mosaic ones for ruminant animals (with extendable wings, inflatable and flowing ones of the float type), and some of them for monogastric animals. Beside the boluses for the forestomach of ruminants there are the hollow bridle for horses, the ear swabs (for resorptive application), the ocular (ocusert), nasal, and vaginal forms (for resorptive therapeutic use), the skin transmembrane therapeutic systems (TTS), the pourable (pour-on and spot-on) forms, 'autodas' osmotic mini-pumps, the depot-forms, the implants, the aerosol (inhalational) forms, the 'ear rings' (ear tags) as well as the dewlaps, the rings (for tails, limbs, and ears) and the medicated feeds and liquids, and the intramammary, intrauterine, and other therapeutic forms.

[Pharmacokinetics of amoxicillin trihydrate in sheep infected experimentally with Corynebacterium pyogenes and Escherichia coli].

A comparative experiment was carried out with sheep that were infected i/v and via the joints with Corynebacterium pyogenes and Escherichia coli, and with normal sheep left as controls. The pharmacokinetic parameters were determined of amoxicillin-trihydrate following its i/m application to all animals in a 20 percent oil suspension. It was found that there was delayed excretion of the antibiotic, and as a rule it was maintained in higher concentrations in the diseased animals.