Publications by authors named "D Drechsel"
The human-specific gene ARHGAP11B is preferentially expressed in neural progenitors of fetal human neocortex and increases abundance and proliferation of basal progenitors (BPs), which have a key role in neocortex expansion. ARHGAP11B has therefore been implicated in the evolutionary expansion of the human neocortex, but its mode of action has been unknown. Here, we show that ARHGAP11B is imported into mitochondria, where it interacts with the adenine nucleotide translocase (ANT) and inhibits the mitochondrial permeability transition pore (mPTP).
View Article and Find Full Text PDFBackground: Baculovirus-mediated expression in insect cells is a powerful approach for protein production. However, many existing methods are time-consuming, offer limited options for protein tagging, and are unsuitable for secreted proteins requiring proteolytic maturation, such as TGF-β family growth factors.
Results: To overcome the limitations of traditional baculovirus expression systems, we engineered "FlexiBAC".
Background: An essential step in ensuring the toxicological safety of cosmetic or personal care products is the evaluation of the skin sensitizing potential of product ingredients.
Objective: We used a standardized protocol from cosmetic trade industry and consumer safety groups to evaluate the sensitization potential of ingredients in 3 commercially available cleansing conditioners.
Methods: A total of 33 ingredients were evaluated.
Article Synopsis
- Many fragrance chemicals used in personal care products can cause allergic reactions, prompting industry limits on their concentrations.
- This study aimed to assess the risk of skin sensitization from daily exposure to these chemicals in cosmetics and personal care items.
- Findings indicate a heightened risk of skin sensitization from leave-on products, like lipstick and face cream, while rinse-off products like shampoo were not linked to this risk, suggesting current safety limits may be inadequate.