Exploration of the correlation of serum polychlorinated biphenyl levels with luteal phase hormonal parameters and infertility in women with or without polycystic ovary syndrome.

Introduction: Polychlorinated biphenyls (PCBs) are organic lipophilic pollutants that accumulate in the body. Previous research has linked PCBs with menstrual function; therefore, this study was undertaken to investigate the correlation of PCBs with luteal phase hormonal parameters of menstrual function at day 21 in a group of non-obese women prior to fertilization (IVF).

Methods: Fifty-eight non-obese Caucasian women from a UK academic center, 29 with polycystic ovary syndrome (PCOS) and 29 without, were recruited.

Serum polychlorinated biphenyl levels and circulating miRNAs in non-obese women with and without polycystic ovary syndrome.

Introduction: Polychlorinated biphenyls (PCBs), organic lipophilic pollutants that accumulate through diet and increase with age, have been associated with polycystic ovary syndrome (PCOS) and shown to affect microRNA (miRNA) expression. This work aimed to determine if PCBs were associated with circulating miRNAs and whether there were any correlations with serum PCB/miRNA levels and hormonal changes.

Methods: 29 non-obese PCOS and 29 healthy control women, with similar age and body mass index (BMI), had their serum miRNAs measured together with 7 indicator PCBs (PCB28, PCB52, PCB101, PCB118, PCB138, PCB153, PCB180) using high resolution gas chromatography coupled with high resolution mass spectrometry.

Persistent Organic Contaminants in Dust from the International Space Station.

Polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane (HBCDD), "novel" brominated flame retardants (NBFRs), organophosphate esters (OPEs), polycyclic aromatic hydrocarbons (PAH), perfluoroalkyl substances (PFAS), and polychlorinated biphenyls (PCBs) were measured in a composite sample of dust from the International Space Station (ISS). Notwithstanding the unique environment from which the dust originated, while concentrations of all target compound classes frequently exceeded the median values in terrestrial indoor microenvironments in the US and western Europe, ISS dust concentrations were generally within the terrestrial range. The relative abundance of the three HBCDD diastereomers is dominated by γ-HBCDD (96.

Association of flame retardants, polybrominated diethyl ethers (PBDEs), with vitamin D in female subjects.

Introduction: A class of flame retardants, polybrominated diethyl ethers (PBDEs), are known endocrine disrupters and may induce the hepatic enzymes CYP24 and CYP3A that promote 25-hydroxylation of vitamin D. Therefore, this study examined the association of PBDEs with vitamin D (25(OH)D) and the active 1,25-dihydrovitamin D (1,25(OH)D) in a cohort of non-obese women.

Methods: 58 female participants (age:31.

Association of polychlorinated biphenyls with vitamin D in female subjects.

Introduction: Polychlorinated biphenyls (PCBs) are known endocrine disrupters. A potentially causal association of PCBs with vitamin D has been reported. Higher body mass index (BMI) is associated with lower PCB levels whilst the strongest association of PCBs with BMI is in non-obese individuals.