Papillary and ductal patterns of mesonephric-like adenocarcinomas are often overlooked: a retrospective revaluation of over 1000 endometrial carcinomas.

Aims: Mesonephric-like adenocarcinoma (MLA) of the endometrium is often a diagnostic challenge, due to its morphological resemblance to other more common Müllerian neoplasms. This study aimed to retrospectively identify overlooked MLA in a large endometrial carcinoma cohort, using a combination of immunohistochemistry (IHC), morphology and KRAS sequencing.

Methods And Results: IHC was conducted on 1094 endometrial carcinomas, identifying 16 potential MLA cases based on GATA3+ and/or TTF1+ and ER- staining patterns, which subsequently underwent detailed histological review, KRAS sequencing and ProMisE molecular classification.

A threshold model to determine the association between race rides and fall risk for early career (apprentice) jockeys.

Objectives: To identify descriptors associated with success in apprentice jockeys and to determine optimum numbers of jockeys for safer race riding.

Design: Retrospective cohort study.

Methods: Incidence-rates for jockey falls and success (wins per 1,000 race-starts), time and number of races spent at different apprentice levels were calculated for 807 apprentice and professional jockeys over 19 years of Thoroughbred flat racing in New Zealand (n = 524,551 race-starts).

Are risk assessment tools more accurate than unstructured judgments in predicting violent, any, and sexual offending? A meta-analysis of direct comparison studies.

We conducted a pre-registered meta-analysis of studies that directly compared the predictive validity of risk assessment tools to unstructured judgments of risk for violent, any, or sexual offending. A total of 31 studies, containing 169 effect sizes from 45,673 risk judgments, met inclusion criteria. Based on the results of three-level mixed-effects meta-regression models, the predictive validity of total scores on risk assessment tools was significantly higher than that of unstructured judgments for predictions of violent, any, and sexual offending.

The unique metabolome of clear cell ovarian carcinoma.

Clear cell ovarian carcinoma (CCOC) is an aggressive malignancy affecting younger women. Despite ovarian cancer subtypes having diverse molecular and clinical characteristics, the mainstay of treatment for advanced stage disease remains cytotoxic chemotherapy. Late stage CCOC is resistant to conventional chemotherapy, which means a suboptimal outcome for patients affected.