Publications by authors named "D Dooley"
Aim: Chemoradiation therapy (CRT) is considered as the first line of treatment for patients with squamous cell carcinoma of the anal canal. Following initial CRT, patients who present with either persistent or locally recurrent disease are treated by surgical intervention. The aim of our study is to determine the prognostic factors associated with failure of CRT and overall mortality in patients with anal squamous cell carcinoma (SCC).
View Article and Find Full Text PDFArticle Synopsis
- Ontologies are key for managing consensus knowledge in areas like biomedical, environmental, and food sciences, but creating and maintaining them requires significant resources and collaboration among experts.
- The Dynamic Retrieval Augmented Generation of Ontologies using AI (DRAGON-AI) leverages Large Language Models and Retrieval Augmented Generation to automate the generation of ontology components, showing high precision in relationship creation and ability to produce acceptable definitions.
- While DRAGON-AI can significantly support ontology development, expert curators remain essential for overseeing the quality and accuracy of the generated content.
Article Synopsis
- A novel Gram-positive thermophilic bacterium, B-768, shows promise as a probiotic and microbial cell factory, but its robustness is not well understood, especially for wild strains.
- Genome sequencing revealed B-768 has the largest known bacterial genome at 3.94 Mbp, featuring enhanced carbohydrate metabolism and capable of utilizing various sugars from biomass hydrolysates.
- Functional genomics indicated that B-768 exhibits different growth phenotypes on xylose and glucose, with a tendency for lactate overproduction on glucose, highlighting its efficient sugar utilization and tolerance to inhibitory conditions.
Background: Within the Open Biological and Biomedical Ontology (OBO) Foundry, many ontologies represent the execution of a plan specification as a process in which a realizable entity that concretizes the plan specification, a "realizable concretization" (RC), is realized. This representation, which we call the "RC-account", provides a straightforward way to relate a plan specification to the entity that bears the realizable concretization and the process that realizes the realizable concretization. However, the adequacy of the RC-account has not been evaluated in the scientific literature.
View Article and Find Full Text PDF