Publications by authors named "D Di Giovanni"
Article Synopsis
- Hospital-acquired infections (HAIs) pose a major global health issue, increasing patient safety risks and causing significant financial strain on healthcare systems.
- A study conducted in Rome analyzed data from over 12,000 hospital patients to assess how HAIs affected hospital costs, revealing a 53.4% increase in average costs for infected patients compared to those without infections.
- The findings underscore the necessity for targeted prevention strategies, as specific types of infections and microbes contribute to higher healthcare expenses, ultimately calling for improved efforts to minimize HAIs in hospitals.
Article Synopsis
- The study examines long-term growth trends in children with Phenylketonuria (PKU) compared to healthy peers, focusing on their body mass index (BMI) and weight-for-length ratio.
- Results show that PKU children's median BMI z-scores were within the normal range, similar to controls, but their weight distributions were broader, particularly peaking around 3 years old.
- Despite comparable rates of overweight between the two groups, the higher prevalence of overweight in the general population raises concerns about the nutritional risks for PKU patients.
Introduction: This study investigates the impact of invasive procedures on healthcare-associated infections (HAI) at Policlinico Universitario Tor Vergata in Rome, Italy, aiming to understand their role in device-associated HAI and to inform prevention strategies.
Methods: A retrospective cohort analysis was conducted, examining mandatory discharge records and microbiology data from 2018 across all departments. The study focused on adult patients, analysing the correlation between invasive procedures and HAI through univariate and multivariate logistic regression.
Inborn errors of immunity (IEI) are a heterogeneous group of hereditary disorders that affect in number and/or function different components of the immune system, resulting in an increased risk and severity of infections, autoimmune diseases, allergic manifestations, autoinflammation and malignancy. Inactivated vaccines are generally safe in these patients, but may be ineffective in some cases, due to difference in immunogenicity. However, live viral and bacterial vaccines may lead to disease, with high morbidity and mortality, so it is essential a previous immunological work-out.
View Article and Find Full Text PDFThe complement system, a vital component of innate immunity, consists of various proteins and pathways crucial for the recognition and elimination of pathogens. In addition, it plays a major role in the initiation of adaptive response through the opsonization of antigens, contributing to B-cell activation and memory maintenance. Deficiencies in complement proteins, particularly C3, can lead to severe and recurrent infections as well as immune complex disorders.
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