Publications by authors named "D Dheepthi"
Ann Indian Acad Neurol
September 2024
Article Synopsis
- Stroke was the second leading cause of death worldwide in 2019, with clopidogrel being a common antiplatelet medication used for prevention in stroke patients, though responses to the drug can vary significantly among individuals.
- Clopidogrel resistance, where the drug fails to effectively inhibit blood clotting, is linked to genetic factors, particularly the CYP2C19 gene, with certain variants (CYP2C19 *2 and *3) affecting treatment outcomes and overall patient prognosis.
- Various testing methods, such as platelet aggregation tests and blood assays, are used to identify clopidogrel resistance, and patients who do not respond well to clopidogrel may benefit from alternative medications like ticagrelor
