Publications by authors named "D Dewran Kocak"
Article Synopsis
- Bitter taste sensing involves type 2 taste receptors (TAS2Rs), specifically TAS2R14, which responds to a wide range of bitter compounds and is highly expressed in tissues outside the mouth.
- Researchers used cryo-electron microscopy to identify two specific structures of TAS2R14 in complex with proteins gustducin (G) and G, revealing key binding sites for cholesterol and the bitter tastant cmpd28.1.
- The study suggests that cholesterol acts as an agonist while cmpd28.1 serves as a positive allosteric modulator, indicating that TAS2R14 has functions that extend beyond just sensing bitter tastes.
Article Synopsis
- - Psychedelic drugs like LSD and psilocybin show promise as treatments for various mental health issues, including depression and PTSD, by activating specific brain receptors (HTR2A).
- - Researchers developed engineered mice to help map and study HTR2A receptors and the neurons that express them, allowing for a clearer understanding of how these psychedelics work in the brain.
- - Behavioral experiments confirmed that psychedelics affect these mice as expected, and further electrical activity studies showed how a neurotransmitter (5-HT) impacts neuron firing, paving the way for deeper insights into the effects of psychedelics.
Modeling the risk factors of women with very severe menopausal symptoms.
J Obstet Gynaecol Res
April 2023
Aim: Individual differences and sociodemographic, gynecological, and cultural characteristics affect the severity of menopausal symptoms. This study aimed to reveal the severity of menopausal symptoms experienced by Turkish women and the risk factors that cause women to experience very severe menopausal symptoms.
Methods: This cross-sectional and descriptive study was conducted with 435 women in menopause.