Objective: To compare the ongoing pregnancy rate per initiated cycle between patients with functional hypothalamic amenorrhea (FHA) and patients with congenital hypogonadotropic hypogonadism (CHH) treated with pulsatile gonadotropin-releasing hormone (GnRH) administration.
Design: Retrospective monocentric cohort study conducted at the University Hospital of Lille from 2004 to 2022.
Setting: Lille University Hospital, Department of Endocrine Gynecology.
Background: In functional hypothalamic amenorrhea (FHA), luteinizing hormone and follicle-stimulating hormone levels show high interindividual variability, which significantly limits their diagnostic value in differentiating FHA from polycystic ovary syndrome (PCOS). Our aim was to profile the LH:FSH ratio in a large sample of patients with well-defined FHA.
Methods: This observational study included all consecutive patients with FHA presenting to the Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, between January 2017 and August 2023.
Background:
Objectives: This perspective seeks to explore the mechanisms and functions of
Methods: A narrative review of all the relevant papers known to the authors was conducted.