Publications by authors named "D Devos"
Article Synopsis
- A diverse range of microbes live around hydrothermal vents on the seafloor, thriving in harsh conditions like high pressure, extreme temperatures, and total darkness.
- Researchers studied three aerobic strains of Planctomycetota isolated from deep-sea iron-rich deposits in the Arctic and Pacific Oceans.
- The genomic analysis showed that these deep-sea strains do not significantly differ from their surface-dwelling relatives, indicating a non-extreme genomic makeup despite their extreme habitat.
Article Synopsis
- Recent analysis of 129 reference genomes and over 5,000 genomes from Planctomycetota revealed a wealth of Biosynthetic Gene Clusters (BGCs), suggesting significant biotechnological potential.
- A total of 987 BGCs were identified in reference genomes, while a much larger number of 22,841 were found across all genomes, with certain classes showing more BGCs per genome than others.
- A striking 88% of these predicted BGCs had no known equivalents in existing databases, highlighting the potential for discovering new compounds and advancing drug research from this unique bacterial phylum.
Parkinson's disease (PD) is primarily characterized by three histological hallmarks: dopaminergic neuronal degeneration, α-synuclein accumulation and iron deposition. Over the last years, neuroimaging, particularly magnetic resonance imaging (MRI) has provided invaluable insights into the mechanisms underlying the disease. However, no imaging method has yet been able to translate α-synuclein protein accumulation and spreading.
View Article and Find Full Text PDFAssessment of Myocardial Fibrosis in Marfan Syndrome Using Cardiac Magnetic Resonance Imaging.
Mol Genet Genomic Med
November 2024
Article Synopsis
- - This study examined heart function and fibrosis in 32 patients with Marfan syndrome (MFS) using cardiac magnetic resonance imaging (CMR).
- - Results showed no focal myocardial fibrosis, but 21% exhibited diffuse fibrosis without a clear link to heart dysfunction; some had reduced left ventricular function.
- - Findings suggest that while diffuse fibrosis occurs in MFS patients, it doesn’t seem to relate to major clinical heart issues, prompting the need for more research to understand its implications.
Importance: Interventions that substantially slow neurodegeneration are needed to address the growing burden of Alzheimer disease (AD) to societies worldwide. Elevated brain iron observed in AD has been associated with accelerated cognitive decline and may be a tractable drug target.
Objective: To investigate whether the brain-permeable iron chelator deferiprone slows cognitive decline in people with AD.