The 'Brussels 4': essential requirements for implantable brain-computer interface user autonomy.

Implantable brain-computer interfaces (iBCIs) hold great promise for individuals with severe paralysis and are advancing toward commercialization. The features required to achieve autonomous use of an iBCI may be under recognized in traditional academic measures of iBCI function and deserve further consideration to achieve successful clinical translation and patient adoption. Here, we present four key considerations to achieve autonomous use, reflecting the authors' perspectives based on discussions during various sessions and workshops across the 10th International BCI Society Meeting, Brussels, 2023: (1) immediate use, (2) easy to use, (3) continuous use, and (4) stable system use.

A mosaic of whole-body representations in human motor cortex.

Understanding how the body is represented in motor cortex is key to understanding how the brain controls movement. The precentral gyrus (PCG) has long been thought to contain largely distinct regions for the arm, leg and face (represented by the "motor homunculus"). However, mounting evidence has begun to reveal a more intermixed, interrelated and broadly tuned motor map.

An Accurate and Rapidly Calibrating Speech Neuroprosthesis.

Background: Brain-computer interfaces can enable communication for people with paralysis by transforming cortical activity associated with attempted speech into text on a computer screen. Communication with brain-computer interfaces has been restricted by extensive training requirements and limited accuracy.

Methods: A 45-year-old man with amyotrophic lateral sclerosis (ALS) with tetraparesis and severe dysarthria underwent surgical implantation of four microelectrode arrays into his left ventral precentral gyrus 5 years after the onset of the illness; these arrays recorded neural activity from 256 intracortical electrodes.

Clinical presentation of celiac disease in adult patients: current real-life experience.

Background And Aims: The clinical presentation of celiac disease (CD) has changed over time with more patients presenting with non-classical symptoms, extra-intestinal manifestations (EIM) or no symptoms. We aimed to investigate the main symptoms/signs leading to the diagnosis of CD in adult patients. As secondary end-point, we evaluated the outcome of gastrointestinal (GI) symptoms following gluten-free diet (GFD).

Management of proctitis in ulcerative colitis and the place of biological therapies.

Introduction: Approximately 20-30% of the patients with ulcerative colitis (UC) may present with isolated proctitis. Ulcerative proctitis (UP) is a challenging condition to manage due to its significant burden in terms of disabling symptoms.

Areas Covered: PubMed was searched up to March 2024 to identify relevant studies on UP.