Publications by authors named "D Deme"

The 21-gene analysis (OncotypeDX) is validated test for pT1-3, pN0-1 with hormone receptor (HR) positive and normal expression of human epidermal growth factor receptor-2 (HER2) breast cancer (BC) to determine the aggressiveness of the disease based on the calculation of Recurrence Score (RS). In this retrospective study the authors correlated pathological characteristics and Recurrence Score (RS) by traditional statistical methods and Observed Oriented Modeling (OOM) in a realistic cohort of BC patients. OncotypeDX tests were performed in 94 tumour specimens of 90 BC patients.

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Introduction: Chronic low grade and intensity inflammation is considered to be a predisposing factor in the development and progression of malignancies. White blood cells play a key role in the process of inflammation. Based on numerous data of the literature, the author demonstrates some results of important meta-analyses and validation studies, which revealed the association between baseline elevated neutrophil-to-lymphocyte ratio (NLR) and the poor prognosis of the malignant diseases.

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Consistent association between elevated baseline serum values and C-reactive protein (CRP), cross-linked fibrin degradation products (D-dimer), lactate dehydrogenase (LDH), decreased baseline serum albumin, absolute lymphocyte count to absolute monocyte count ratio (LMR), elevated absolute neutrophil count to absolute lymphocyte count ratio (NLR), elevated platelet count to absolute lymphocyte count ratio (PLR), and between some combinations of these biomarkers and the short overall survival of patients with malignant diseases has already been reported. These biomarkers are independent prognostic factors for cancer. Here, the most significant biomarker combination of these values was searched and studied in real-life advanced cancer patients of a single center.

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