A Combined Computational and Experimental Analysis of PLA and PCL Hybrid Nanocomposites 3D Printed Scaffolds for Bone Regeneration.

A combined computational and experimental study of 3D-printed scaffolds made from hybrid nanocomposite materials for potential applications in bone tissue engineering is presented. Polycaprolactone (PCL) and polylactic acid (PLA), enhanced with chitosan (CS) and multiwalled carbon nanotubes (MWCNTs), were investigated in respect of their mechanical characteristics and responses in fluidic environments. A novel scaffold geometry was designed, considering the requirements of cellular proliferation and mechanical properties.

Computational Fluid Dynamic Analysis of customised 3D-printed bone scaffolds with different architectures.

Through the recent years, tissue engineering has been proven as a solid substitute of autografts in the stimulation of bone tissue regeneration, through the development of three dimensional (3D) porous matrices, commonly known as scaffolds. In this work, we analysed two scaffold structures with 500μm pore size, by performing computational fluid dynamics simulations, to compare permeability, Wall Shear Stress (WSS), velocity and pressure distributions. Taking into account those parameters the geometry named as "PCL-50" was the best to anticipate showing a superior performance in supporting cell growth due to the improved flow characteristics in the scaffold.

A computational and experimental mechanical study of nanocomposites for 3D printed scaffolds with a new geometry.

We present a combined study of the mechanical properties of 3D printed scaffolds made by nanocomposite materials based on polycaprolactone (PCL). The geometry and dimensions of the three different systems is the same. Τhe porosity is 50% for all systems.

Adhesion strength and anti-tumor agents regulate vinculin of breast cancer cells.

The onset and progression of cancer are strongly associated with the dissipation of adhesion forces between cancer cells, thus facilitating their incessant attachment and detachment from the extracellular matrix (ECM) to move toward metastasis. During this process, cancer cells undergo mechanical stresses and respond to these stresses with membrane deformation while inducing protrusions to invade the surrounding tissues. Cellular response to mechanical forces is inherently related to the reorganization of the cytoskeleton, the dissipation of cell-cell junctions, and the adhesion to the surrounding ECM.

Comparison of the Weil and Triple Weil Osteotomies: A Clinical Retrospective Study.

Introduction: The Weil and triple Weil osteotomies are two widely used procedures in the surgical treatment of metatarsalgia. The aim of this comparative retrospective study was to evaluate the functional results and determine the complications of the two types of osteotomies in a series of patients who underwent surgery due to third rocker metatarsalgia.

Material And Methods: In this paper, 71 patients were included between September 2015 and October 2020.