Publications by authors named "D Delgado Ochoa"
Statins are the primary drugs used to prevent cardiovascular disease by inhibiting the HMG-CoA reductase, an enzyme crucial for the synthesis of LDL cholesterol in the liver. A significant number of patients experience adverse drug reactions (ADRs), particularly musculoskeletal problems, which can affect adherence to treatment. Recent clinical guidelines, such as those from the Clinical Pharmacogenetics Implementation Consortium (CPIC) in 2022, recommend adjusting rosuvastatin doses based on genetic variations in the and genes to minimize ADRs and improve treatment efficacy.
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- The introduction discusses challenges in achieving flat closure during oncologic mastectomy in obese patients and introduces the angel wing (AW) technique as a solution.
- A retrospective study at an academic center evaluated the safety of the AW technique by analyzing postoperative arm lymphedema (AL) and decreased range of motion (dROM) in patients who underwent mastectomy with and without this technique.
- Results showed no significant difference in the incidence of AL or dROM between the AW and non-AW groups, suggesting that the AW technique is a safe option for achieving effective surgical outcomes in obese patients postmastectomy.
Article Synopsis
- The Open Targets Platform is an open-source knowledge base designed for identifying and prioritizing drug targets with enhanced data and tools.
- Significant updates include a revamped target-disease associations page featuring interactive elements and a new Target Prioritisation view, allowing users to evaluate targets based on clinical relevance and safety.
- The platform now also incorporates a direction of effect assessment from various evidence sources, illustrating how genetic variations impact target functions, thereby aiding in the understanding of disease treatment mechanisms.
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- Robot-assisted (RA) surgery shows potential benefits for urinary tract and pelvic floor reconstruction (UTPFR), but research on its use is limited and needs to grow.
- An International Consultation on Incontinence-Research Society (ICI-RS) meeting suggested prioritizing multicenter studies to assess RA UTPFR's clinical effectiveness, safety, and training needs.
- The proposal emphasizes the need for cost-utility models, improved surgeon training, and embracing new technologies like digitalization to enhance surgical outcomes.
Article Synopsis
- Ketamine is increasingly used recreationally, leading to health issues like ketamine-induced uropathy (KIU), which has lower urinary tract symptoms and may affect the upper urinary tract.
- The 2024 ICI-RS meeting focused on KIU, employing literature reviews, expert talks, and group discussions to examine its clinical and research aspects comprehensively.
- Research highlights include bladder fibrosis mechanisms, the potential for reversing fibrosis, and the relationship between ketamine use and urinary symptoms, suggesting the need for further studies on the systemic effects and psychological dependency of users.