Publications by authors named "D De Michele"

Plasma membrane repair (PMR) restores membrane integrity of cells, preventing cell death in vital organs, and has been studied extensively in skeletal muscle. Dysferlin, a sarcolemmal Ca-binding protein, plays a crucial role in PMR in skeletal muscle. Previous studies have suggested that PMR uses membrane trafficking and membrane fusion, similar to neurotransmission.

View Article and Find Full Text PDF

Pulmonary disorders affect 40%-80% of individuals with obesity. Respiratory muscle dysfunction is linked to these conditions; however, its pathophysiology remains largely undefined. Mice subjected to diet-induced obesity (DIO) develop diaphragm muscle weakness.

View Article and Find Full Text PDF

Cardiomyocytes require the HSP70 chaperone BiP to maintain proteostasis in the endoplasmic reticulum (ER) following cardiac stress. The adenylyl transferase (AMPylase) FICD is increasingly recognized to regulate BiP activity through the post-translational addition of an adenosine monophosphate moiety to BiP surface residues. However, the physiological impact of FICD-mediated BiP regulation in the context of cardiovascular health is unknown.

View Article and Find Full Text PDF

Pulmonary disorders impact 40-80% of individuals with obesity. Respiratory muscle dysfunction is linked to these conditions; however, its pathophysiology remains largely undefined. Mice subjected to diet-induced obesity (DIO) develop diaphragmatic weakness.

View Article and Find Full Text PDF

Research suggests that exposure to social networking sites portraying a thin and often sexualized beauty ideal reduces young women's body satisfaction, while exposure to body-positive content improves it. However, it is unclear whether sexualization could impair the beneficial effects of body-positivity messages. Young Italian women were exposed to one of three experimental conditions showing sexualized beauty ideals, sexualized body positivity, or non-sexualized body positivity that appeared either on Instagram (Study 1, = 356) or TikTok (Study 2, = 316).

View Article and Find Full Text PDF