The Distribution and Role of M1 and M2 Macrophages in Aneurysm Healing after Platinum Coil Embolization.

Background And Purpose: Impairment of macrophage polarization from a proinflammatory macrophage type 1 (M1) population to an anti-inflammatory macrophage type 2 (M2) population is a hallmark of poor wound healing. In this study, we aimed to evaluate the distribution of M1 and M2 macrophages and to analyze their association with healing in aneurysms embolized by endovascular coiling.

Materials And Methods: Elastase-induced aneurysms were created in female rabbits and subsequently embolized with platinum coils.