Abnormal Porphyrin Metabolism in Autism Spectrum Disorder and Therapeutic Implications.

Autism spectrum disorder (ASD) is a mosaic of neurodevelopmental conditions composed of early-onset social interaction and communication deficits, along with repetitive and/or restricted patterns of activities, behavior, and interests. ASD affects around 1% of children worldwide, with a male predominance. Energy, porphyrin, and neurotransmitter homeostasis are the key metabolic pathways affected by heavy metal exposure, potentially implicated in the pathogenesis of ASD.

The Peptide A-3302-B Isolated from a Marine Bacterium sp. Inhibits HSV-2 Infection by Preventing the Viral Egress from Host Cells.

Herpesviruses are highly prevalent in the human population, and frequent reactivations occur throughout life. Despite antiviral drugs against herpetic infections, the increasing appearance of drug-resistant viral strains and their adverse effects prompt the research of novel antiherpetic drugs for treating lesions. Peptides obtained from natural sources have recently become of particular interest for antiviral therapy applications.

Spontaneous conversion of prenyl halides to acids: application in metal-free preparation of deuterated compounds under mild conditions.

Here we reveal a simple generation of deuterium halide (DX) from common and inexpensive reagents readily available in a synthetic chemistry laboratory, i.e. prenyl-, allyl-, and propargyl halides, under mild conditions.

Contemporary concepts in treatment planning, reconstruction and rehabilitation of the maxillofacial region: an overview of methods used in practice.

Treatment planning, reconstruction and rehabilitation of maxillofacial and dental defects have always been a challenge for a maxillofacial surgeon. Reconstruction of the oral cavity is often a difficult task as it involves the restoration of both the esthetic or cosmetic form as well as the preoperative function. Understanding the oral cavity anatomy as well the functional capacities of its various subunits is required to achieve good results.