Publications by authors named "D Danila"
(1) Background: Burn injuries in children present a significant public health concern due to their potential for severe physical and psychological impact. (2) Methods: This study investigates the determinants of pediatric burn severity by analyzing the interplay of demographic and environmental factors. Through a retrospective analysis of pediatric burn cases over five years, encompassing patient demographics, burn causative agents, and clinical outcomes, this research aims to identify significant predictors of burn severity.
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- - The study focused on identifying factors that enhance the success of genomic profiling in metastatic castration-resistant prostate cancer (mCRPC) through bone biopsies, highlighting the importance of selecting the right metastatic sites.
- - An analysis of 243 men revealed that 59% of biopsies provided sufficient material for genomic profiling, with key factors influencing success including PSA levels, FDG PET results, and the number of biopsy samples taken.
- - Findings suggest that targeting areas of higher metabolic activity and those with lower CT attenuation increases the likelihood of obtaining viable genetic material, which is vital for effective patient management in mCRPC.
Purpose: Patients with microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) and high tumor mutational burden (TMB-H) prostate cancers are candidates for pembrolizumab. We define the genomic features, clinical course, and response to immune checkpoint blockade (ICB) in patients with MSI-H/dMMR and TMB-H prostate cancers without MSI [TMB-H/microsatellite stable (MSS)].
Experimental Design: We sequenced 3,244 tumors from 2,257 patients with prostate cancer.
Aim: The aim of the present study is to assess some characteristics of blunt hepatic and splenic injuries in children, the non-operative management (NOM) procedures and efficiency, over a 5-year period in a tertiary hospital for children. We conducted a retrospective study on 32 patients with blunt liver and/or spleen injuries. Age, gender, mechanism of injury, hemoglobin and hematocrit levels, lenght of stay and bedrest, imaging diagnosis, hemostatics and transfusions, treatment, and discharge status were evaluated.
View Article and Find Full Text PDFPurpose: HOXB13 is an androgen receptor (AR) coregulator specifically expressed in cells of prostatic lineage. We sought to associate circulating tumor cell (CTC) HOXB13 expression with outcomes in men with mCRPC treated with abiraterone or enzalutamide.
Experimental Design: We conducted a retrospective analysis of the multicenter prospective PROPHECY trial of mCRPC men (NCT02269982, n = 118) treated with abiraterone/enzalutamide.