Publications by authors named "D Dale"
Development of the Pancreatic Ducts and Their Contribution to Organogenesis.
Adv Anat Embryol Cell Biol
September 2024
The pancreas is a dual-function organ, with exocrine cells that aid in digestion and endocrine cells that regulate glucose homeostasis. These cell types share common progenitors and arise from the embryonic ducts. Early signaling events in the embryonic ducts shape the neonatal, adolescent, and adult exocrine and endocrine pancreas.
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- A phase 3 trial was conducted to evaluate the efficacy and safety of mavorixafor, an oral medication, in individuals with WHIM syndrome, a rare immunodeficiency disorder caused by genetic mutations.
- Participants were randomly assigned to receive either mavorixafor or a placebo for 52 weeks, with the study focusing on the time above certain white blood cell counts as the primary endpoint.
- Results showed mavorixafor significantly increased white blood cell counts, reduced infection rates and severity, and was well tolerated without serious adverse events occurring during the study.
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- - Severe chronic neutropenia leads to a low absolute neutrophil count, increasing the risk of bacterial infections, but can be treated effectively with G-CSF injections, raising questions about potential risks of further blood disorders.
- - Research from the Severe Chronic Neutropenia International Registry indicates that while there are low risks of conditions like MDS or AML, certain patient groups may be more vulnerable.
- - New oral treatments are being investigated as alternatives to G-CSF, including neutrophil elastase inhibitors and gene therapy, but their safety, effectiveness, and costs have yet to be fully evaluated.
Background: Coinfection with malaria and typhoid fever is a major public health issue in developing countries. In endemic areas, including Ethiopia, people are at risk of acquiring both malaria and typhoid fever at the same time. Therefore, this study aimed to determine the magnitude of malaria-typhoid fever coinfection in febrile patients attending hospital at Southern Ethiopia.
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