Publications by authors named "D DUMITRASCU"

Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder, affecting 3-5% of the global population and significantly impacting patients' quality of life and healthcare resources. Alongside physical symptoms such as abdominal pain and altered bowel habits, many individuals experience psychological comorbidities, including anxiety and depression. Recent research has highlighted the critical role of the gut microbiota in IBS, with dysbiosis, characterized by an imbalance in microbial diversity, frequently observed in patients.

View Article and Find Full Text PDF

Introduction: Chronic nausea and vomiting are symptoms of a wide range of gastrointestinal and non-gastrointestinal conditions. Diagnosis can be challenging and requires a systematic and well-structured approach. If the initial investigation for structural, toxic and metabolic disorders is negative, digestive motility and gut-brain interaction disorders should be assessed.

View Article and Find Full Text PDF

Liver cirrhosis is a chronic, progressive condition characterized by fibrosis and architectural distortion of the liver, leading to impaired liver function and severe complications. Accurately predicting these complications is crucial to the improvement of patient outcomes. Therefore, this study aimed to evaluate the accuracy of various non-invasive biomarkers and clinical scores in assessing the risk of complications among cirrhotic patients.

View Article and Find Full Text PDF
Article Synopsis
  • Hepatic disease is a major issue for children with cystic fibrosis (CF), but its link to specific genetic factors remains unclear; this study investigates these connections in a Romanian pediatric population.
  • The study involved 71 children with CF, comparing 25 with hepatic disease to 46 without, collecting data on CFTR genotypes and SERPINA1 alleles; results showed a common genotype (DF508/DF508) but no significant genetic associations with hepatic disease.
  • Although the study found no strong links between genetics and liver complications, children with hepatic disease showed higher fibrosis scores and a trend towards delayed CF diagnosis, highlighting the need for early identification and monitoring of liver health in CF patients.
View Article and Find Full Text PDF