Technical Considerations in the Pig-To-Human Kidney Xenotransplant: A Historical Perspective.

As the limited supply of human donor organs remains the greatest barrier to renal transplantation, porcine renal xenografts have the potential to reduce the organ shortage. Recent attempts at using genetically engineered porcine renal xenografts have met with technical and functional problems. It is theorized that if transplantation of the en bloc kidneys had been performed: (1) the double nephron mass would provide normal renal function, (2) the procedure would be easier and safer by using the larger and thicker donor aorta and vena cava instead of the smaller and thinner-wall renal vessels, and (3) the operative procedure would be less time consuming because there are only 2 anastomoses to perform instead of a minimum of 4.

Desmodinosides A-E: New Flavonoid C-glycosides from Desmodium heterocarpon var. stigosum with hepatoprotective and antifungal activity.

Five new flavonoid C-glycosides named desmodinosides A-E (1-5) and one known compound, apigenin 6-C-β-d-xylopyranosyl-2''-O-β-D-glucopyranoside (6) have been isolated from the methanol extract of the aerial parts of Desmodium heterocarpon var. stigosum. These compounds were determined by 1D and 2D-NMR and HR-MS spectroscopies.

Chemical constituents with senolytic activity from the stems of Limacia scandens.

While screening senotherapeutics from natural products, seven undescribed chemicals, two syringylglycerol derivatives, two cyclopeptides, one tigliane analogue, and two chromone derivatives, as well as six known compounds were isolated from the stems of Limacia scandens. The structures of compounds were elucidated through spectroscopic data analysis, including 1D and 2D NMR, HRESIMS, and CD data. All compounds were tested in replicative senescent human dermal fibroblasts (HDFs) to determine their potential as senotherapeutic agents to specifically target senescent cells.

Benzylisoquinoline Alkaloids from the Stems of and Their Potential as Autophagy Inhibitors.

is traditionally used to treat depression and affective disorders in Malaysia. The chemical compositions have been reported to include bisbenzylisoquinoline and aporphine-type alkaloids in the genus Lour., but studies on the components of have rarely been reported.

Chemical constituents of Antidesma bunius aerial parts and the anti-AGEs activity of selected compounds.

Thirty-three natural products were isolated from the aerial parts of Antidesma bunius, Euphorbiaceae, a plant used in Vietnamese traditional medicine against rheumatoid arthritis. All compounds were reported the first time for this species, and nine constituents resembled undescribed natural products, noticeably three coumarinolignans with 2,2-dimethyl-1,3-dioxolane moiety, two cyclopeptides, and two furofuran-type lignans connected with a phenylpropanoid moiety. The individual structures were elucidated by combining NMR and MS data, and their configuration was established by NOESY and ECD experiments and NMR calculations.