Deficiency Promotes Hyperlipidemia, Inflammation, and Atherosclerosis in LDL Receptor Knockout Mice.

Background: Genetic variants at the gene locus are strongly associated with plasma lipid traits and the risk of coronary artery disease in humans. Here, we analyzed the consequences of deficiency on lipid metabolism and atherosclerotic lesion formation in atherosclerosis-susceptible mice.

Methods: mice were crossed onto the background to generate double-knockout mice () and fed a semisynthetic, modified AIN76 diet (0.

An integrated versatile lab-on-a-chip platform for the isolation and nucleic acid-based detection of pathogens.

Aim: Processing of the samples in molecular diagnostics is complex and labor-intensive. An integrated and automated platform for sample preparation and nucleic acid-based detection can significantly relieve this burden for the users.

Results: We present a prototype of a versatile and integrated platform for the detection of pathogens in various liquid media.

Atypical granular cell tumor occurring in an individual with Noonan syndrome treated with growth hormone.

We report a large infiltrating atypical granular cell tumor in a child with Noonan syndrome. Even though granular cell tumors are rare in childhood, five cases have been reported in children with Noonan syndrome. This study compares these different cases and explores the possibility of activation of the granular cell by the Ras pathway.