Assessing Adolescent Vaping Norms and Perceptions in a Statewide Multi-Community Project.

: Adolescent e-cigarette use has increased dramatically in recent years and is quickly becoming a serious public health issue. While studies have identified the influence of social norms on the use of traditional cigarettes, few have examined these factors in the context of e-cigarettes and other vaping devices. : The goal of this study was to examine social norms predictors of past 30-day e-cigarette use among high school students in 10 communities located in Minnesota.

Early detection of obstructive coronary artery disease in the asymptomatic high-risk population: objectives and study design of the EARLY-SYNERGY trial.

Background: Coronary artery disease (CAD) burden for society is expected to steeply increase over the next decade. Improved feasibility and efficiency of preventive strategies is necessary to flatten the curve. Acute myocardial infarction (AMI) is the main determinant of CAD-related mortality and morbidity, and predominantly occurs in individuals with more advanced stages of CAD causing subclinical myocardial ischemia (obstructive CAD; OCAD).

Fatal postoperative intracranial hypotension-associated venous congestion after elective laminectomy.

Postoperative intracranial hypotension-associated venous congestion is a rare complication that features radiologic characteristics suggestive of hypoxic ischaemic encephalopathy without systemic hypoxia or hypotension actually occurring. This makes the condition prone to being misidentified as a complication of anaesthesia. In this case, a patient undergoing emergency haematoma evacuation after a previous lumbar laminectomy lost cerebrospinal fluid rapidly and accidentally via a wound drain.

Influence of the choice of software package on the outcome of semiquantitative MR myocardial perfusion analysis.

Purpose: To assess the repeatability and reproducibility of semiquantitative magnetic resonance (MR) perfusion analysis performed by using different software packages.

Materials And Methods: The study protocol was approved by the institutional ethics committee. Informed consent was obtained from each patient.

Discovery of a potential allosteric ligand binding site in CDK2.

Cyclin-dependent kinases (CDKs) are key regulatory enzymes in cell cycle progression and transcription. Aberrant activity of CDKs has been implicated in a number of medical conditions, and numerous small molecule CDK inhibitors have been reported as potential drug leads. However, these inhibitors exclusively bind to the ATP site, which is largely conserved among protein kinases, and clinical trials have not resulted in viable drug candidates, attributed in part to the lack of target selectivity.