High- and Moderate-Risk Variants Among Breast Cancer Patients and Healthy Donors Enrolled in Multigene Panel Testing in a Population of Central Russia.

Assessments of breast cancer (BC) risk in carriers of pathogenic variants identified by gene panel testing in different populations are highly in demand worldwide. We performed target sequencing of 78 genes involved in DNA repair in 860 females with BC and 520 age- and family history-matched controls from Central Russia. Among BC patients, 562/860 (65.

Metal-Free Synthesis of 2-(per)Fluoroalkyl-3-nitro Indoles via Intramolecular Cyclization of Amides.

A metal-free intramolecular cyclization of N-acyl amides for the synthesis of 3-nitro-2-(per)fluoroalkyl indoles is reported. Good functional group tolerance and a broad range of substrates are the features of this approach. The developed method is easy to operate and is suitable for the preparation of 2-difluoromethyl/trifluoromethyl/perfluoroethyl/perfluoropropyl indoles in yields of 84 to 99%.

Gene Mutations: Implications for Hereditary Cancer Syndromes.

Malignant neoplasms, including pancreatic cancer and melanoma, are major global health challenges. This study investigates melanoma pancreatic syndrome, a rare hereditary tumor syndrome associated with gene mutations. mutations contribute to a lifetime risk of melanoma ranging from 28% to 67%.

The Physicochemical Characterization of New "Green" Epoxy-Resin Hardener Made from PET Waste.

"Green" thermally stable hardener was synthesized from a PET waste. The rigid molecular linear structure of the new hardener suggests that it will provide the polymer matrix with the necessary physical and mechanical characteristics. It also allows the expectation that cured matrix based on this hardener can provide increased toughness.

[Morphological substantiation of laparoscopic suturing of stomach ulcer with formation of a covered perforation].

Objective: Morphological substantiation of laparoscopic suturing of gastric ulcer with formation of a covered perforation.

Material And Methods: To analyze morphological tissue reaction in surgical area, we used 12 Chinchilla rabbits. All animals were divided into 2 groups by 6 animals.