The safety and efficacy of vaccination is a subject contentious in the public mind. Despite overwhelming evidence of their benefits to public health, COVID-19 and human papilloma virus (HPV) vaccines have been the focus of intense concerns. While the original phase III trials and post-market phase IV studies have continued to show their benefits and positive safety profile, some authors have attempted to reassess the original trial data, purporting to showing hidden harms for both COVID-19 and HPV vaccines.
View Article and Find Full Text PDFBackground: Depression is a common nonmotor complication in Parkinson's disease (PD). However, few studies have evaluated the efficacy of first-line psychological therapies for depression in this patient population.
Objectives: This randomized controlled trial evaluated the efficacy of interpersonal psychotherapy (IPT), an empirically validated intervention for depression that focuses on the bidirectional relationship between mood disturbance and interpersonal and social stressors.
Introduction: Elevated plasma homocysteine (Hcy) is associated with an increased risk of developing neurodegenerative diseases; however, its relationship with the apolipoprotein E (APOE) ε4 allele has not been well characterized.
Methods: Participants clinically diagnosed with Alzheimer's disease or mild cognitive impairment (AD/MCI), frontotemporal dementia, Parkinson's disease, or cerebrovascular disease were stratified by the presence of the APOE ε4 allele. Volumetric magnetic resonance imaging, plasma amyloid/tau/neurodegeneration biomarkers, and cognitive performance were quantified.
High-quality cancer research is crucial to both save lives and improve quality of life. Spurious findings, however, impedes these laudable goals by misleading research efforts and creating research waste that is inherently difficult to counteract. Irreproducible research is intrinsically wasteful, and unsustainable over the long term.
View Article and Find Full Text PDFPurpose: As people with long-standing disabling conditions age, the interplay between pre-existing conditions and new comorbidities can present unique challenges. Therefore, the current study explored relationships between resilience and health, health promotion, and quality of life among older adults living with multiple sclerosis (MS).
Method: Adults recruited from National MS Society chapters completed a mailed survey about their health, health promotion, and well-being.