Participant selection procedures in qualitative research: experiences and some points for consideration.

Qualitative research is widely embraced in the social sciences and education. Among the different traditional, modern, and community-oriented qualitative methodologies, we have drawn on our experiences to adopt seven qualitative methodologies: auto/ethnography, narrative inquiry, participatory action research, ethnography, case study, grounded theory, and phenomenology. Despite the abundance of literature on qualitative methodologies, there is still a need for a more focused exploration of participant selection procedures in qualitative studies.

The Enigma That Is ROHHAD Syndrome: Challenges and Future Strategies.

Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation (ROHHAD) is a rare syndrome presenting in early childhood associated with a high risk of mortality between 50 and 60%. It is characterised by rapid, early onset of obesity between 1.5-7 years, along with central hypoventilation and hypothalamic dysfunction, such as central hypothyroidism, hyperprolactinemia, disorders of sodium and water balance, growth hormone deficiency, adrenocortical insufficiency, or disorders of puberty and features of autonomic dysregulation.

Benzene-1,3-disulfonyl Fluoride Mediated Synthesis of Glycosyl Fluorides from Glycosyl Hemiacetals.

We developed an efficient method for synthesizing glycosyl fluorides from glycosyl hemiacetals using benzene-1,3-disulfonyl fluoride () as the fluorinating agent in combination with the base DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) under mild conditions.

Nanoconjugate Carrying pH-Responsive Transferrin Receptor-Targeted Hesperetin Triggers Triple-Negative Breast Cancer Cell Death through Oxidative Attack and Assemblage of Pro-Apoptotic Proteins.

Triple-negative breast cancer (TNBC) is recognized as a major aggressive subtype of breast cancer due to its expeditious worsening growth, extensive metastatic capability, and recalcitrance to standard current treatments. Hesperetin (HSP), a natural bioflavonoid from citrus fruits, demonstrates pronounced anticancer efficacy, but its hydrophobicity limits its clinical development. The present study reports the fabrication of a biocompatible and pH-responsive transferrin (TF) receptor-targeted HSP-loaded poly(lactic--glycolic acid) (PLGA) nanobioconjugate (PLGA-HSP-TF NPs) and the exploration of its and antineoplastic potential.

Complications of excess weight seen in two tier 3 paediatric weight management services: an observational study.

Background: Children and young people living with severe obesity experience a range of complications of excess weight (CEW); however the prevalence of complications is not well defined. We have evaluated baseline characteristics and CEW of patients from two UK tier 3 paediatric weight management services.

Methods: All new patients aged 2-17 years seen from March 2022 to February 2023 were included.