Publications by authors named "D D Corum"
Article Synopsis
- Danofloxacin, a fluoroquinolone antibiotic, is effective against bacterial infections in fish, but its pharmacokinetics vary based on fish size, impacting its medicinal effectiveness.!* -
- A study conducted on rainbow trout demonstrated that larger fish have higher plasma concentrations and overall drug efficacy of danofloxacin compared to smaller fish, with measurements taken after oral administration.!* -
- While larger fish show increased therapeutic efficacy, their higher drug concentrations in tissues raise concerns about potential residue and withdrawal time for safe consumption.!*
Article Synopsis
- * The study, called KOMET-001, was conducted in multiple countries and involved dose-escalation and validation phases, with patients in specific molecular subtypes receiving varying doses of ziftomenib over 28-day cycles.
- * Results indicated that 83 patients were treated with ziftomenib from September 2019 to August 2022, and the findings are crucial for determining the drug's safety and effectiveness for future phases of clinical testing.
Background: Enrofloxacin (ENR) is a fluoroquinolone antibiotic approved for use in sheep of all ages. The body composition and metabolic capability change with age. These changes may alter the pharmacokinetics of drugs and thus their effect.
View Article and Find Full Text PDF1. The aim of this study was to determine the pharmacokinetics of meloxicam (MLX, 1 mg/kg body weight (BW)), ketoprofen (KETO, 2 mg/kg BW), and tolfenamic acid (TA, 2 mg/kg BW) in chukar partridge () following intravenous (IV) administration.2.
View Article and Find Full Text PDFAkt3 regulates mitochondrial content in endothelial cells through the inhibition of PGC-1α nuclear localization and is also required for angiogenesis. However, whether there is a direct link between mitochondrial function and angiogenesis is unknown. Here we show that Akt3 depletion in primary endothelial cells results in decreased uncoupled oxygen consumption, increased fission, decreased membrane potential, and increased expression of the mitochondria-specific protein chaperones, HSP60 and HSP10, suggesting that Akt3 is required for mitochondrial homeostasis.
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