Publications by authors named "D D Billadeau"
During endosomal recycling, Sorting Nexin 17 (SNX17) facilitates the transport of numerous membrane cargo proteins by tethering them to the Retriever complex. Despite its importance, the mechanisms underlying this interaction have remained elusive. Here, we provide biochemical, structural, cellular, and proteomic analyses of the SNX17-Retriever interaction.
View Article and Find Full Text PDFGerminal center (GC) formation, which is an integrant part of humoral immunity, involves energy-consuming metabolic reprogramming. Rag-GTPases are known to signal amino acid availability to cellular pathways that regulate nutrient distribution such as the mechanistic target of rapamycin complex 1 (mTORC1) pathway and the transcription factors TFEB and TFE3. However, the contribution of these factors to humoral immunity remains undefined.
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- Researchers studied mutations in a gene that affects a key protein involved in cell signaling, which is linked to severe health issues like impaired immunity in patients.
- The mutations were found to disrupt normal cell behavior by promoting excessive cell growth and responses to immune signals, specifically T cell receptor stimulation.
- The mutant protein was shown to interfere with a regulatory protein, leading to heightened activity of important signaling pathways that contribute to cell growth and survival.
Article Synopsis
- HD-PTP (or PTPN23) plays a key role in the formation of multivesicular bodies by aiding endosomal sorting complexes, which is important for cellular transport.
- Researchers created mice with reduced HD-PTP levels to study its physiological effects, discovering these mice displayed lipodystrophy and impaired signaling in white adipose tissue related to various pathways, including RAS/MAPK and PI3K/AKT.
- The study found that while EGF binding was normal, there was reduced signaling activation due to changes in cholesterol distribution within cells, suggesting a crucial role for HD-PTP in both signaling regulation and maintaining fat tissue health.
Vesicle trafficking is a fundamental process that allows for the sorting and transport of specific proteins (i.e., "cargoes") to different compartments of eukaryotic cells.
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