Evaluation of phytochemical constituents and sedative-hypnotic activity of the methanol leaf extract of in mice.

Background And Aim: Sedative drugs mostly cause dose-dependent depression of the central nervous system which results in hypnosis and anesthesia possibly; however, these agents are associated with some side effects ranging respiratory, digestive, immune system dysfunctions, tolerance, cognitive function deterioration, and physical dependence; hence, investigations of newer and safer agents are, therefore, imperative. The current study was aimed at investigating the sedative-hypnotic (S-H) effects of the methanol leaf extract of in mice.

Materials And Methods: Phytochemical screening of the leaf extract was conducted, and S-H activity of the plant extract was evaluated.

Local Anaesthetic Effect of Methanolic Leaves Extract of Lannea schimperi (Hoschst. Ex Rich) Eng.

Background: Local anaesthetics provide relief from pain when applied locally to nerve tissue by blocking conduction of sensory nerve impulse from the receptor to the brain cortex.

Objective: This study aimed at evaluating local anaesthetic activity of the methanolic leaves extract of Lannea schimperi.

Methods: Six groups of five animals were used; groups I-IV were used for intracutaneous wheal test in guinea pigs for infiltration anaesthesia, while group V and VI were used for guinea pig corneal reflex method of surface anaesthesia.

Phytochemistry, Antinociceptive and Anti-inflammatory Actvities of Methanolic Leaves Extract of Lannea schimperi (Hoschst. Ex Rich) ENG.

Background: Pain whether acute or chronic, peripheral or central is believed to originate from inflammation and inflammatory response. The potential toxicity of antinociceptive and antiinflammatory agents such as non steroidal anti-inflammatory drugs (NSAIDs) necessitates sourcing for less toxic alternative drugs. Many natural substances have been used for the management of pain and inflammation with success traditionally.

Effect of oral administration of aqueous whole extract of cassytha filiformis on haematograms and plasma biochemical parameters in rats.

Introduction: We evaluated the sub-chronic toxicity of the aqueous herbal extract prepared from Cassytha filiformis and administered daily for 28 days at dose levels (250, 500, and 1000 mg/kg bw) in male wistar albino rats. The LD50 of the aqueous extract was determined.

Methods: The effects on body weights, organ weights, and certain haematological and plasma biochemical parameters were measured as indices of organ toxicity.

Investigation into the nephrotoxicity of Nigerian bonny light crude oil in albino rats.

The effect of bonny-light crude oil was assessed in adult albino rats. The rats were administered with 200, 400, and 800 mg/kg body weight of the crude oil orally for 7 days. Fluid intake was measured daily, initial and final animal body was recorded.