Publications by authors named "D Czock"
Purpose: We investigated the effects of a multidomain lifestyle intervention conducted in older adults at increased risk for dementia on participants' diet.
Methods: Secondary analyses of the cluster-randomized AgeWell.de-trial, testing a multidomain intervention (optimization of nutrition and medication, enhancement of physical, social and cognitive activity) in older adults at increased dementia risk.
Quantitative systems pharmacology (QSP) models are rarely applied prospectively for decision-making in clinical practice. We therefore aimed to operationalize a QSP model for potas-sium homeostasis to predict potassium trajectories based on spironolactone administrations. For this purpose, we proposed a general workflow that was applied to electronic health records (EHR) from patients treated in a German tertiary care hospital.
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- The study examined the relationship between the CAIDE dementia risk score and modifiable factors in the LIBRA score among 807 German participants at high risk for Alzheimer's.
- Results showed that higher cognitive activity and fruit/vegetable intake were linked to lower CAIDE scores, while diabetes increased risk.
- The findings suggest that different dementia risk scores may classify individuals differently, highlighting the impact of lifestyle choices on dementia risk.
Background: General practitioners (GPs) play a crucial role in identifying cognitive impairment and dementia and providing post-diagnostic care. This study investigates (1) how promising GP consider lifestyle changes to maintain cognitive performance in general, (2) GP beliefs about the power of modifiable health and lifestyle factors to maintain cognitive performance, and (3) whether those beliefs vary by GP age.
Methods: As part of the AgeWell.