Publications by authors named "D Cristian Morsucci"
Exp Cell Res
January 2017
Article Synopsis
- Polycystin-2 (PC2) is a cation channel involved in calcium transport and cell signaling in kidney cells, and its dysfunction can lead to autosomal dominant polycystic kidney disease (ADPKD).
- Research showed that varying external calcium levels significantly affect PC2 activity, with high calcium increasing currents and zero calcium decreasing them, indicating PC2's sensitivity to calcium levels.
- The study found that the calcium sensing receptor (CaSR) plays a role in modulating PC2 functionality, as activation of CaSR mimicked high calcium effects, suggesting a new regulatory mechanism for PC2 in renal epithelial cells.
