Publications by authors named "D Cramer"
Objective: To determine whether a multimodal assay combining serum microRNA with protein biomarkers and metadata improves triage assessment of an adnexal mass.
Methods: Serum samples from 468 training subjects (191 cancer cases and 277 benign adnexal mass controls or healthy controls) were analyzed for seven protein biomarkers and 180 miRNA. Circulating analyte data were combined with age and menopausal status (metadata) into a neural network model to classify samples as cases or controls.
Background: Tea and coffee are the most frequently consumed beverages in the world. Green tea in particular contains compounds with potential anti-cancer effects, but its association with survival after ovarian cancer is uncertain.
Methods: We investigated the associations between tea and coffee consumption before diagnosis and survival using data from 10 studies in the Ovarian Cancer Association Consortium.
Background: Cancers of ductal origin often express glycoprotein mucin 1 (MUC1), also known as CA15.3, with higher levels leading to poor prognosis. Conversely, anti-MUC1 antibodies develop in some patients, leading to better prognosis.
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- The study examined risk factors for epithelial ovarian cancer (EOC) among women of different racial and ethnic backgrounds, including Asian, Hispanic, Native Hawaiian/Pacific Islander, and White participants.
- Findings indicated that oral contraceptive (OC) use and childbirth (parity) were generally associated with lower EOC risk across all groups, especially in Native Hawaiian/Pacific Islander and Asian women.
- Significant differences in EOC risk factors were detected among the ethnic groups, suggesting that including more diverse populations in research could improve prevention strategies for ovarian cancer.