Publications by authors named "D Craig Rudolph"
KRASG12C selective inhibitors, such as sotorasib and adagrasib, have raised hopes of targeting other KRAS mutant alleles in cancer patients. We report that KRAS wild-type amplified tumor models are sensitive to treatment with the small molecule KRAS inhibitors BI-2493 and BI-2865. These pan-KRAS inhibitors directly target the "OFF" state of KRAS and result in potent anti-tumor activity in pre-clinical models of cancers driven by KRAS mutant proteins.
View Article and Find Full Text PDFBTZ043 is an 8-nitro-1,3-benzothiazin-4-one with potency against multidrug-resistant . Low solubility and hepatic metabolism are linked to poor oral bioavailability. Amorphous drug nanoparticles (ADN) were formulated to improve the bioavailability.
View Article and Find Full Text PDFStudies in SIV-infected macaques show that the virus reservoir is particularly refractory to conventional suppressive antiretroviral therapy (ART). We posit that optimized ART regimens designed to have robust penetration in tissue reservoirs and long-lasting antiviral activity may be advantageous for HIV or SIV remission. Here we treat macaques infected with RT-SHIV with oral emtricitabine/tenofovir alafenamide and long-acting cabotegravir/rilpivirine without (n = 4) or with (n = 4) the immune activator vesatolimod after the initial onset of viremia.
View Article and Find Full Text PDFArticle Synopsis
- - The experiment at Lawrence Berkeley National Laboratory aimed to produce a superheavy element with an atomic number of 114 or greater by bombarding an actinide target with a ^{50}Ti beam.
- - Using the Berkeley Gas-filled Separator, researchers successfully isolated and implanted produced Livermorium (Lv) ions into a high-tech detector system, observing two decay chains linked to ^{290}Lv.
- - The measured production cross-section of the process was 0.44 picobarns at a specific energy, marking the first published evidence of superheavy element production near the "island of stability" with this method, paving the way for future discoveries beyond element Z=118.
Article Synopsis
- Researchers conducted a study on the chemical reactivity of superheavy elements nihonium (Nh) and moscovium (Mc) using a new chromatography setup, revealing new insights into their properties.
- The isotopes of Mc were produced at GSI Helmholtzzentrum in Germany, and their interaction with silicon oxide and gold surfaces was examined, providing the first measurements for their adsorption enthalpy.
- The findings showed that Nh and Mc have weaker interactions with silicon oxide compared to their lighter counterparts, but display higher reactivity than neighboring elements copernicium and flerovium due to significant relativistic effects.